The International Cardiac Arrest Research Consortium
Electroencephalography Database
by Amorim,
Edilberto; Zheng, Wei-Long; Ghassemi, Mohammad M.; Aghaeeaval, Mahsa; Kandhare,
Pravinkumar; Karukonda, Vishnu; Lee, Jong Woo; Herman, Susan T.; Sivaraju,
Adithya; Gaspard, Nicolas; Hofmeijer, Jeannette; van Putten, Michel J. A. M.;
Sameni, Reza; Reyna, Matthew A.; Clifford, Gari D.; Westover, M. Brandon
Critical Care Medicine 51(12):p
1802-1811, December 2023.
OBJECTIVES:
To develop the International Cardiac Arrest Research
(I-CARE), a harmonized multicenter clinical and electroencephalography database
for acute hypoxic-ischemic brain injury research involving patients with
cardiac arrest.
DESIGN:
Multicenter cohort, partly prospective and partly
retrospective.
SETTING:
Seven academic or teaching hospitals from the United States
and Europe.
PATIENTS:
Individuals 16 years old or older who were comatose after
return of spontaneous circulation following a cardiac arrest who had continuous
electroencephalography monitoring were included.
INTERVENTIONS:
Not applicable.
MEASUREMENTS AND MAIN RESULTS:
Clinical and electroencephalography data were harmonized and
stored in a common Waveform Database-compatible format. Automated spike
frequency, background continuity, and artifact detection on
electroencephalography were calculated with 10-second resolution and summarized
hourly. Neurologic outcome was determined at 3–6 months using the best Cerebral
Performance Category (CPC) scale. This database includes clinical data and
56,676 hours (3.9 terabytes) of continuous electroencephalography data for
1,020 patients. Most patients died (n = 603, 59%), 48 (5%) had severe
neurologic disability (CPC 3 or 4), and 369 (36%) had good functional recovery
(CPC 1–2). There is significant variability in mean electroencephalography
recording duration depending on the neurologic outcome (range, 53–102 hr for
CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in
frequency for at least 1 hour was seen in 258 patients (25%) (19% for CPC 1–2
and 29% for CPC 3–5). Burst suppression was observed for at least 1 hour in 207
(56%) and 635 (97%) patients with CPC 1–2 and CPC 3–5, respectively.
CONCLUSIONS:
The I-CARE consortium electroencephalography database
provides a comprehensive real-world clinical and electroencephalography dataset
for neurophysiology research of comatose patients after cardiac arrest. This
dataset covers the spectrum of abnormal electroencephalography patterns after
cardiac arrest, including epileptiform patterns and those in the
ictal-interictal continuum.
