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Showing posts with label ICU admission. Show all posts
Showing posts with label ICU admission. Show all posts

Tuesday, 29 March 2022

 

Intensive care unit capacity and mortality in older adults: a three nations retrospective observational cohort study

 

by Ran Abuhasira, Matthew Anstey, Victor Novack, Somnath Bose, Daniel Talmor and Lior Fuchs 

 

Annals of Intensive Care volume 12, Article number: 20 (2022) Published: 04 March 2022

Background

Intensive care unit (ICU) admissions among older adults are expected to increase, while the benefit remains uncertain. The availability of ICU beds varies between hospitals and between countries and is an important factor in the decision to admit older adults in the ICU. We aimed to assess if a non-restrictive approach to ICU older adults admission is associated with a corresponding change in survival.

Methods

Retrospective cohort study that included patients ≥ 80 years who were admitted to each of the three participating hospitals in Australia, Israel, and the United States (USA), between the years 2006–2015, each with distinct ICU capacities and admission criteria. The primary outcomes were in-hospital mortality and all-cause mortality at 6, 12, 18, and 24 months following index hospitalization.

Results

The cohort included 62,866 patients with a mean age of 85.9 ± 4.6 years and 58.8% were women. The ICU admission rates were 22.5%, 2.6% and 2.3% in USA, Australia, and Israel, respectively. We constructed a model for ICU admissions based on the USA cohort (highest availability of ICU beds) and then calculated the expected probabilities for the Israeli and Australian cohorts. For the patients in the highest quintile of the admission model, actual ICU admission rates were 67.6% in USA, 22.1% in Australia and 6.0% in Israel. Of these, in-hospital death rates were 52.3% in Israel, 29.8% in Australia, and 22.1% in USA. Two years after hospital discharge, the survival rates in the USA and Australia were 53%, while in Israel 48%.

Conclusion

ICU admission of adults ≥ 80 years is associated with increased in-hospital survival compared to ward admission, but survival rates 2 years later are similar.

Wednesday, 5 January 2022

 

Patterns of ICU admissions and outcomes in patients with solid malignancies over the revolution of cancer treatment

by Clara Vigneron, Julien Charpentier, Sandrine Valade, Jérôme Alexandre, Samy Chelabi, Lola-Jade Palmieri, Nathalie Franck, Valérie Laurence, Jean-Paul Mira, Matthieu Jamme and Frédéric Pène 

Annals of Intensive Care volume 11, Article number: 182 (2021) Published: 24 December 2021

Background

Major therapeutic advances including immunotherapy and targeted therapies have been changing the face of oncology and resulted in improved prognosis as well as in new toxic complications. The aim of this study is to appraise the trends in intensive care unit (ICU) admissions and outcomes of critically ill patients with solid malignancies. We performed a retrospective single-centre study over a 12-year period (2007–2018) including adult patients with solid malignancies requiring unplanned ICU admission. Admission patterns were classified as: (i) specific if directly related to the underlying cancer; (ii) non-specific; (iii) drug-related or procedural adverse events.

Results

1525 patients were analysed. Lung and gastro-intestinal tract accounted for the two main tumour sites. The proportion of patients with metastatic diseases increased from 48.6% in 2007–2008 to 60.2% in 2017–2018 (p = 0.004). Critical conditions were increasingly related to drug- or procedure-related adverse events, from 8.8% of ICU admissions in 2007–2008 to 16% in 2017–2018 (p = 0.01). The crude severity of critical illness at ICU admission did not change over time. The ICU survival rate was 77.4%, without any significant changes over the study period. Among the 1279 patients with complete follow-up, the 1-year survival rate was 33.2%. Independent determinants of ICU mortality were metastatic disease, cancer in progression under treatment, admission for specific complications and the extent of organ failures (invasive and non-invasive ventilation, inotropes/vasopressors, renal replacement therapy and SOFA score). One-year mortality in ICU-survivors was independently associated with lung cancer, metastatic disease, cancer in progression under treatment, admission for specific complications and decision to forgo life-sustaining therapies.

Conclusion

Advances in the management and the prognosis of solid malignancies substantially modified the ICU admission patterns of cancer patients. Despite underlying advanced and often metastatic malignancies, encouraging short-term and long-term outcomes should help changing the dismal perception of critically ill cancer patients.

 

 

 

 

 

Tuesday, 25 February 2020

Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis



by Wen-Cheng Chao, Chien-Hua Tseng, Chieh-Liang Wu, Sou-Jen Shih, Chi-Yuan Yi and Ming-Cheng Chan 

Annals of Intensive Care volume 10, Article number: 17 (2020)

Background
High glycemic variability (GV) is common in critically ill patients; however, the prevalence and mortality association with early GV in patients with sepsis remains unclear.
Methods
This retrospective cohort study was conducted in a medical intensive care unit (ICU) in central Taiwan. Patients in the ICU with sepsis between January 2014 and December 2015 were included for analysis. All of these patients received protocol-based management, including blood sugar monitoring every 2 h for the first 24 h of ICU admission. Mean amplitude of glycemic excursions (MAGE) and coefficient of variation (CoV) were used to assess GV.
Results
A total of 452 patients (mean age 71.4 ± 14.7 years; 76.7% men) were enrolled for analysis. They were divided into high GV (43.4%, 196/452) and low GV (56.6%, 256/512) groups using MAGE 65 mg/dL as the cut-off point. Patients with high GV tended to have higher HbA1c (6.7 ± 1.8% vs. 5.9 ± 0.9%, p < 0.01) and were more likely to have diabetes mellitus (DM) (50.0% vs. 23.4%, p < 0.01) compared with those in the low GV group. Kaplan–Meier analysis showed that a high GV was associated with increased 30-day mortality (log-rank test, p = 0.018). The association remained strong in the non-DM (log-rank test, p = 0.035), but not in the DM (log-rank test, p = 0.254) group. Multivariate Cox proportional hazard regression analysis identified that high APACHE II score (adjusted hazard ratio (aHR) 1.045, 95% confidence interval (CI) 1.013–1.078), high serum lactate level at 0 h (aHR 1.009, 95% CI 1.003–1.014), having chronic airway disease (aHR 0.478, 95% CI 0.302–0.756), high mean day 1 glucose (aHR 1.008, 95% CI 1.000–1.016), and high MAGE (aHR 1.607, 95% CI 1.008–2.563) were independently associated with increased 30-day mortality. The association with 30-day mortality remained consistent when using CoV to assess GV.
Conclusions
We found that approximately 40% of the septic patients had a high early GV, defined as MAGE > 65 mg/dL. Higher GV within 24 h of ICU admission was independently associated with increased 30-day mortality. These findings highlight the need to monitor GV in septic patients early during an ICU admission.

Tuesday, 22 October 2019

Emergency Department to ICU Time Is Associated With Hospital Mortality: A Registry Analysis of 14,788 Patients From Six University Hospitals in The Netherlands*



Groenland, Carline N. L.; Termorshuizen, Fabian; Rietdijk, Wim J. R.; van den Brule, Judith; Dongelmans, Dave A.; de Jonge, Evert; de Lange, Dylan W.; de Smet, Anne Marie G. A.; de Keizer, Nicolette F.; Weigel, Joachim D.; Jewbali, Lucia S. D.; Boersma, Eric; den Uil, Corstiaan A.


Objectives: Prolonged emergency department to ICU waiting time may delay intensive care treatment, which could negatively affect patient outcomes. The aim of this study was to investigate whether emergency department to ICU time is associated with hospital mortality.
Design, Setting, and Patients: We conducted a retrospective observational cohort study using data from the Dutch quality registry National Intensive Care Evaluation. Adult patients admitted to the ICU directly from the emergency department in six university hospitals, between 2009 and 2016, were included. Using a logistic regression model, we investigated the crude and adjusted (for disease severity; Acute Physiology and Chronic Health Evaluation IV probability) odds ratios of emergency department to ICU time on mortality. In addition, we assessed whether the Acute Physiology and Chronic Health Evaluation IV probability modified the effect of emergency department to ICU time on mortality. Secondary outcomes were ICU, 30-day, and 90-day mortality.
Interventions: None.
Measurements and Main Results: A total of 14,788 patients were included. The median emergency department to ICU time was 2.0 hours (interquartile range, 1.3–3.3 hr). Emergency department to ICU time was correlated to adjusted hospital mortality (p < 0.002), in particular in patients with the highest Acute Physiology and Chronic Health Evaluation IV probability and long emergency department to ICU time quintiles: odds ratio, 1.29; 95% CI, 1.02–1.64 (2.4–3.7 hr) and odds ratio, 1.54; 95% CI, 1.11–2.14 (> 3.7 hr), both compared with the reference category (< 1.2 hr). For 30-day and 90-day mortality, we found similar results. However, emergency department to ICU time was not correlated to adjusted ICU mortality (p = 0.20).
Conclusions: Prolonged emergency department to ICU time (> 2.4 hr) is associated with increased hospital mortality after ICU admission, mainly driven by patients who had a higher Acute Physiology and Chronic Health Evaluation IV probability. We hereby provide evidence that rapid admission of the most critically ill patients to the ICU might reduce hospital mortality.

Tuesday, 18 October 2016

Association Among ICU Congestion, ICU Admission Decision, and Patient Outcomes

Association Among ICU Congestion, ICU Admission Decision, and Patient Outcomes

Kim, S et al

Critical Care Medicine: October 2016 - Volume 44 - Issue 10 - p 1814–1821

Objectives: To employ automated bed data to examine whether ICU occupancy influences ICU admission decisions and patient outcomes. 

Design: Retrospective study using an instrumental variable to remove biases from unobserved differences in illness severity for patients admitted to ICU. Setting: Fifteen hospitals in an integrated healthcare delivery system in California. Patients: Seventy thousand one hundred thirty-three episodes involving patients admitted via emergency departments to a medical service over a 1-year period between 2008 and 2009. Interventions: None. 
Measurements and Main Results: A third of patients admitted via emergency department to a medical service were admitted under high ICU congestion (more than 90% of beds occupied). High ICU congestion was associated with a 9% lower likelihood of ICU admission for patients defined as eligible for ICU admission. We further found strong associations between ICU admission and patient outcomes, with a 32% lower likelihood of hospital readmission if the first inpatient unit was an ICU. Similarly, hospital length of stay decreased by 33% and likelihood of transfer to ICU from other units—including ICU readmission if the first unit was an ICU—decreased by 73%. 
Conclusions: High ICU congestion is associated with a lower likelihood of ICU admission, which has important operational implications and can affect patient outcomes. By taking advantage of our ability to identify a subset of patients whose ICU admission decisions are affected by congestion, we found that, if congestion were not a barrier and more eligible patients were admitted to ICU, this hospital system could save approximately 7.5 hospital readmissions and 253.8 hospital days per year. These findings could help inform future capacity planning and staffing decisions.

Thursday, 26 March 2015

Characteristics and outcomes of patients admitted to ICU following activation of the Medical Emergency Team

Characteristics and outcomes of patients admitted to ICU following activation of the Medical Emergency Team: Impact of introducing a two-tier response system. Critical Care Medicine, April 2015, Vol. 43(4), p.765-73.

Aneman, A., et al.

http://journals.lww.com/ccmjournal/Abstract/2015/04000/Characteristics_and_Outcomes_of_Patients_Admitted.6.aspx

To determine the impact of introducing a two-tier system for responding to deteriorating ward patients on ICU admissions after medical emergency team review.

Thursday, 9 December 2010

Association between ICU admission during morning rounds and mortality

Association between ICU admission during morning rounds and mortality. Chest, 2009, Vol. 136(6), p. 1489 - 1495.

Afessa, B., et al.

http://chestjournal.chestpubs.org/content/136/6/1489.full

No previous study has evaluated the association between admission to ICUs during round time and patient outcome. The objective of this study was to determine the association between round-time ICU admission and patient outcome.

The ICU 'golden hour' vs morning admissions

The ICU 'golden hour' vs morning admissions. Chest, 2009, vol. 136(6), p. 1449-1451.

Freire, AX and Yataco, JC.

http://chestjournal.chestpubs.org/content/136/6/1449.full

The authors present a robust observation from a single academic institution identifying an association between ICU admissions during morning teaching rounds and increased severity-adjusted mortality.

Wednesday, 16 December 2009

Association between ICU admission during morning rounds and mortality

Association between ICU admission during morning rounds and mortality. CHEST, Dec. 2009 vol. 136(6), p. 1489-1495.

Afessa, B. et al.

http://chestjournal.chestpubs.org/content/136/6/1489.full

Background: No previous study has evaluated the association between admission to ICUs during round time and patient outcome. The objective of this study was to determine the association between round-time ICU admission and patient outcome. Conclusions: Patients admitted to the ICU during morning rounds have higher severity of illness and mortality rates.

Wednesday, 11 November 2009

ICU admissions after actual or planned hospital discharge

ICU admissions after actual or planned hospital discharge. Chest, vol. 136(5), Nov. 2009, p.1257-1262.

Chawla, S., et al.

http://chestjournal.chestpubs.org/content/136/5/1257.full

Unexpected ICU admissions may result from early or premature discharge from the hospital. We sought to determine the incidence, clinical characteristics, and outcomes of patients admitted to the ICU after actual or planned hospital discharge and to analyze whether the need for ICU admission was related or unrelated to the associated hospitalization.

Tuesday, 11 March 2008

Evaluation of ICU Admission Criteria and Diagnostic Methods for Patients With Severe Community - Acquired Pneumonia : Current Practice Survey

Author(s): Marcos I . Restrepo
ISSUE: 2008 ; VOL 133 ; PART 3 (2008-March)
Journal Title:Access Chest ( Formerly : Diseases of the Chest ) From Free Medical Journals . com (/1995 - /Embargo: 1 year) Customer Notes: 1997 v111/1
Print Location: Macclesfield

From Proquest NHS (01/1997 - 11/2006)
Page: 828 - 829

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