ABO blood types and sepsis mortality

 

ABO blood types and sepsis mortality

Theis S. Itenov, Daniel I. Sessler, Ashish K. Khanna, Sisse R. Ostrowski, Pär I. Johansson, Christian Erikstrup, Ole B. Pedersen, Sofie L. Rygård, Lars B. Holst, Morten H. Bestle, Lars Hein, Anne Lindhardt, Hami Tousi, Mads H. Andersen, Thomas Mohr, Jens D. Lundgren

Annals of Intensive Care volume 11, Article number: 61 (2021)

Background

We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.

Results

We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.

Conclusion

Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

Letter: Blood type A associates with critical COVID-19 and death in a Swedish cohort

 

Letter: Blood type A associates with critical COVID-19 and death in a Swedish cohort

Critical Care volume 24, Article number: 496 (2020) 

Coronavirus disease 2019 (COVID-19) is primarily associated with respiratory failure, but both renal and circulatory failure is common in patients that require critical care or die of the disease [1]. A recently published GWAS showed a strong association between severe COVID-19 and the ABO blood group locus in a cohort from Italy and Spain, with a higher risk for patients with blood group A [2]. This is consistent with data on susceptibility to COVID-19 being associated with blood group in Chinese [3]. Although the GWAS dataset did not include data on mortality, there is a preliminary report in an American cohort that blood group A is associated with both severity of COVID-19 and death [4]…