Effect of statin therapy on mortality from infection and sepsis

Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and observational studies. Critical Care 2014, 18:R71

You-Dong Wan, et al.

http://ccforum.com/content/pdf/cc13828.pdf

Observational data have suggested that statin therapy may reduce mortality in patients with 
infection and sepsis; however, results from randomized studies are contradictory and do not 
support the use of statins in this context. Here, we performed a meta-analysis to investigate 
the effects of statin therapy on mortality from infection and sepsis.

Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock

Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study. Critical care, vol. 15(4), July 2011.

Dessap, AM, et al.

http://ccforum.com/content/15/4/R171

Recent publications suggest potential benefits from statins as a preventive or adjuvant therapy in sepsis. Whether ongoing statin therapy should be continued or discontinued in patients admitted in the intensive care unit (ICU) for sepsis is open to question.