Systematic inflammatory response criteria in defining severe sepsis

Systematic inflammatory response criteria in defining severe sepsis. NEJM, March 2015.

Kaukonen, K.M., et al.

http://www.nejm.org/doi/full/10.1056/NEJMoa1415236#t=article

The consensus definition of severe sepsis requires suspected or proven infection, organ failure, and signs that meet two or more criteria for the systemic inflammatory response syndrome (SIRS). We aimed to test the sensitivity, face validity, and construct validity of this approach.