Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium

Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium: a post-hoc analysis of a double-blind, randomized, placebo-controlled study. Critical Care 2011, 15:R215

Devlin, JW., et al.

http://ccforum.com/content/15/5/R215

The outcome of patients with delirium has been linked to the particular delirium symptoms identified with ICDSC evaluation. However, no ICU delirium prevention or treatment strategy published to date reports the impact of interventions on time to resolution of individual delirium symptoms. We hypothesized that the pattern of delirium symptom resolution would differ between patients receiving quetiapine vs. placebo. In this post-hoc analysis, we compared the delirium symptoms evaluated by the ICDSC within our previous randomized study in terms of the time to first resolution and the duration of each delirium symptom.