Risk factors and outcomes for prolonged versus brief fever: a prospective cohort study. Critical care, August 2012, 16(4): R150
Seguin, P., et al.
http://ccforum.com/content/16/4/R150/abstract
Prolonged fever occurs with infectious and noninfectious diseases but is poorly studied in intensive care units. The aims of this prospective multicenter noninterventional study were to determine the incidence and etiologies of prolonged fever in critically ill patients and compare outcomes for prolonged fever and short-lasting fever.
Tuesday, 4 September 2012
Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis
Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis. Critical care, August 2012, 16(4): R158
Calisto, K.L., et al.
http://ccforum.com/content/16/4/R158/abstract
Hyperglycemia and insulin resistance has been associated with a worse outcome in sepsis. Although tight glycaemic control through insulin therapy has been shown to reduce morbidity and mortality rates, the effect of intensive insulin therapy in patients with severe sepsis is controversial because of the increased risk of serious adverse events related to hypoglycemia.
Calisto, K.L., et al.
http://ccforum.com/content/16/4/R158/abstract
Hyperglycemia and insulin resistance has been associated with a worse outcome in sepsis. Although tight glycaemic control through insulin therapy has been shown to reduce morbidity and mortality rates, the effect of intensive insulin therapy in patients with severe sepsis is controversial because of the increased risk of serious adverse events related to hypoglycemia.
Impact of surveillance of hospital-acquired infections on the incidence of ventilator-associated pneumonia in intensive care units
Impact of surveillance of hospital-acquired infections on the incidence of ventilator-associated pneumonia in intensive care units: a quasi-experimental study. Critical Care, August 2012; 16(4): R161.
Benet, T., et al.
http://ccforum.com/content/16/4/R161/abstract
The preventive impact of hospital-acquired infection (HAI) surveillance is difficult to assess. Our objective was to investigate the effect of HAI surveillance disruption on ventilator-associated pneumonia (VAP) incidence.
Benet, T., et al.
http://ccforum.com/content/16/4/R161/abstract
The preventive impact of hospital-acquired infection (HAI) surveillance is difficult to assess. Our objective was to investigate the effect of HAI surveillance disruption on ventilator-associated pneumonia (VAP) incidence.
Acute kidney injury patients have worse long-term outcomes
Acute kidney injury patients have worse long-term outcomes especially in the immediate post-ICU period. Critical care, August 2012, 16(4): 148.
Hoste, E.A.J. and De Corte, W.
http://ccforum.com/content/16/4/148/abstract
AKI is associated with worse outcome n the acute phase of acute illness, but also in the chronic phase. In a recent large Danish study, 1-year mortality was lower in AKI patients compared to non-AKI patients [1]. Mortality was most important during the first 50 days after ICU admission, while after 2 months the survival curves were similar in AKI and non-AKI patients.
Hoste, E.A.J. and De Corte, W.
http://ccforum.com/content/16/4/148/abstract
AKI is associated with worse outcome n the acute phase of acute illness, but also in the chronic phase. In a recent large Danish study, 1-year mortality was lower in AKI patients compared to non-AKI patients [1]. Mortality was most important during the first 50 days after ICU admission, while after 2 months the survival curves were similar in AKI and non-AKI patients.
Serious adverse effects associated with the use of rituximab
Serious adverse effects associated with the use of rituximab: a critical care perspective. Critical care, August 2012; 16(4):231.
Kasi, P.M., et al.
http://ccforum.com/content/16/4/231/abstract
The purpose of this review is to focus on the severe complications associated with the use of rituximab that require critical care. Management and prevention strategies for the most common complications are also discussed along with some examples of its uses within the critical care setting.
Kasi, P.M., et al.
http://ccforum.com/content/16/4/231/abstract
The purpose of this review is to focus on the severe complications associated with the use of rituximab that require critical care. Management and prevention strategies for the most common complications are also discussed along with some examples of its uses within the critical care setting.
An evaluation of the impact of antibiotic stewardship in reducing the use of high-risk antibiotics
An evaluation of the impact of antibiotic stewardship in reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings. J.Antimicrob. Chemother., Aug 2012 [epub]
Aldeyab, M.A., et al.
http://www.ncbi.nlm.nih.gov/pubmed/22899806?dopt=Abstract
To evaluate the impact of a high-risk antibiotic stewardship programme on reducing antibiotic use and on hospital Clostridium difficile infection (CDI) incidence rates. A secondary objective was to present the possible utility of time-series analysis as an antibiotic risk classification tool.
Aldeyab, M.A., et al.
http://www.ncbi.nlm.nih.gov/pubmed/22899806?dopt=Abstract
To evaluate the impact of a high-risk antibiotic stewardship programme on reducing antibiotic use and on hospital Clostridium difficile infection (CDI) incidence rates. A secondary objective was to present the possible utility of time-series analysis as an antibiotic risk classification tool.
Thursday, 16 August 2012
Neuro--ventilatory efficiency and extubation readiness in critically ill patients
Neuro--ventilatory efficiency and extubation readiness in critically ill patients. Critical care, July 2012, 16: R143.
Liu, L., et al.
http://ccforum.com/content/16/4/R143/abstract
Based on the hypothesis that weaning failure from mechanical ventilation is caused by respiratory demand exceeding the capacity of the respiratory muscles, we evaluated whether extubation failure could be characterized by increased respiratory drive and impaired efficiency to generate inspiratory pressure and ventilation.
Liu, L., et al.
http://ccforum.com/content/16/4/R143/abstract
Based on the hypothesis that weaning failure from mechanical ventilation is caused by respiratory demand exceeding the capacity of the respiratory muscles, we evaluated whether extubation failure could be characterized by increased respiratory drive and impaired efficiency to generate inspiratory pressure and ventilation.
Depressive symptoms in spouses of older patients with severe sepsis
Depressive symptoms in spouses of older patients with severe sepsis. Critical care medicine, August 2012, Vol. 40(8), p.2335-41.
Davydow, D., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Depressive_symptoms_in_spouses_of_older_patients.10.aspx
Objective: To examine whether spouses of patients with severe sepsis are at increased risk for depression independent of the spouse’s presepsis history, whether this risk differs by sex, and is associated with a sepsis patient’s disability after hospitalization.
Davydow, D., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Depressive_symptoms_in_spouses_of_older_patients.10.aspx
Objective: To examine whether spouses of patients with severe sepsis are at increased risk for depression independent of the spouse’s presepsis history, whether this risk differs by sex, and is associated with a sepsis patient’s disability after hospitalization.
Light and the outcome of the critically ill
Light and the outcome of the critically ill: an observational cohort study. Critical care, July 2012, 16: R132.
Castro, R.A., et al.
http://ccforum.com/content/16/4/R132/abstract
Light before and during acute illness has been associated with both benefit and harm in animal models and small human studies. Our objective was to determine the associations of light duration (photoperiod) and intensity (insolation) before and during critical illness with hospital mortality in ICU patients. Based on the 'winter immunoenhancement' theory, we tested the hypothesis that a shorter photoperiod before critical illness is associated with improved survival.
Castro, R.A., et al.
http://ccforum.com/content/16/4/R132/abstract
Light before and during acute illness has been associated with both benefit and harm in animal models and small human studies. Our objective was to determine the associations of light duration (photoperiod) and intensity (insolation) before and during critical illness with hospital mortality in ICU patients. Based on the 'winter immunoenhancement' theory, we tested the hypothesis that a shorter photoperiod before critical illness is associated with improved survival.
Development and pilot testing of a decision aid for surrogates of patients with prolonged mechanical ventilation
Development and pilot testing of a decision aid for surrogates of patients with prolonged mechanical ventilation. Critical care medicine, August 2012, Vol. 40(8), p.2327-34.
Cox, C.E., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Development_and_pilot_testing_of_a_decision_aid.9.aspx
Shared decision making is inadequate in intensive care units. Decision aids can improve decision making quality, though their role in an intensive care units setting is unclear. We aimed to develop and pilot test a decision aid for shared decision makers of patients undergoing prolonged mechanical ventilation.
Cox, C.E., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Development_and_pilot_testing_of_a_decision_aid.9.aspx
Shared decision making is inadequate in intensive care units. Decision aids can improve decision making quality, though their role in an intensive care units setting is unclear. We aimed to develop and pilot test a decision aid for shared decision makers of patients undergoing prolonged mechanical ventilation.
Identifying family members who may struggle in the role of surrogate decision maker
Identifying family members who may struggle in the role of surrogate decision maker. Critical care medicine, August 2012, Vol. 40(8), p.2281-86.
Majesko, A., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Identifying_family_members_who_may_struggle_in_the.2.aspx
Although acting as a surrogate decision maker can be highly distressing for some family members of intensive care unit patients, little is known about whether there are modifiable risk factors for the occurrence of such difficulties.
Majesko, A., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/08000/Identifying_family_members_who_may_struggle_in_the.2.aspx
Although acting as a surrogate decision maker can be highly distressing for some family members of intensive care unit patients, little is known about whether there are modifiable risk factors for the occurrence of such difficulties.
Do earplugs stop noise driving critical care patients into delirium?
Do earplugs stop noise driving critical care patients into delirium? Critical care, July 2012, 16: 139.
Mills, G.H. and Bourne, R.S.
http://ccforum.com/content/16/4/139/abstract
Quality sleep is a problem for the critically ill who are cared for in an environment where interventions night and day are common, staff members are constantly present in relatively high numbers, and treatment is accompanied by a range of changing warning tones and alarms and lights. These critical care units are generally designed without a focus on patient comfort, sleep, and rest and often lack access to appropriate natural daylight. To add to this problem, critical illness, particularly sepsis, disrupts circadian rhythms and sleep patterns, and disruption of circadian rhythms, in turn, impairs immunity and contributes to delirium.
Mills, G.H. and Bourne, R.S.
http://ccforum.com/content/16/4/139/abstract
Quality sleep is a problem for the critically ill who are cared for in an environment where interventions night and day are common, staff members are constantly present in relatively high numbers, and treatment is accompanied by a range of changing warning tones and alarms and lights. These critical care units are generally designed without a focus on patient comfort, sleep, and rest and often lack access to appropriate natural daylight. To add to this problem, critical illness, particularly sepsis, disrupts circadian rhythms and sleep patterns, and disruption of circadian rhythms, in turn, impairs immunity and contributes to delirium.
Critical care nurses' judgement of pain status
Critical care nurses' judgement of pain status: A case study design. Intensive & critical care nursing, August 2012, Vol.28(4), p.215-23.
Connor, L.O.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000055/abstract?rss=yes
In the performance of their professional activities, critical care nurses routinely make important judgements based on uncertain, fallible and inter-substitutable data. It is anticipated that this study will make visible the strategy by which critical care nurses use and combine multiple fallible cues, of which little is known, to reach a judgement about the pain status of the ventilated patient after coronary artery bypass graft (CABG) surgery.
Connor, L.O.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000055/abstract?rss=yes
In the performance of their professional activities, critical care nurses routinely make important judgements based on uncertain, fallible and inter-substitutable data. It is anticipated that this study will make visible the strategy by which critical care nurses use and combine multiple fallible cues, of which little is known, to reach a judgement about the pain status of the ventilated patient after coronary artery bypass graft (CABG) surgery.
How can nurses facilitate patient's transitions from intensive care?
How can nurses facilitate patient's transitions from intensive care? Intensive & critical care nursing, August 2012, Vol. 28(4), p.224-233.
Haggstrom, M., et al.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000031/abstract?rss=yes
Intensive care patients often experience feelings of powerlessness and vulnerability when being transferred from an intensive care unit to a general ward. The aim of this study was to develop a grounded theory of nurses care for patients in the ICU transitional care process.
Haggstrom, M., et al.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000031/abstract?rss=yes
Intensive care patients often experience feelings of powerlessness and vulnerability when being transferred from an intensive care unit to a general ward. The aim of this study was to develop a grounded theory of nurses care for patients in the ICU transitional care process.
End of life in intensive care
End of life in intensive care: Is transfer home an alternative? Intensive & critical care nursing, August 2012, Vol. 28(4), p.234-241.
Tellett, L., et al.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000079/abstract?rss=yes
The past decade has witnessed an increased focus on improving the quality of end of life care internationally. This has resulted in the development of specific health policy work streams to support patient choice and improve standards of care and patient experience. One concept well explored in areas outside of critical care is that of home care at the end of life. This paper seeks to challenge assumptions and practices about the options for transferring the critically ill patient home at end of life.
Tellett, L., et al.
http://www.intensivecriticalcarenursing.com/article/PIIS0964339712000079/abstract?rss=yes
The past decade has witnessed an increased focus on improving the quality of end of life care internationally. This has resulted in the development of specific health policy work streams to support patient choice and improve standards of care and patient experience. One concept well explored in areas outside of critical care is that of home care at the end of life. This paper seeks to challenge assumptions and practices about the options for transferring the critically ill patient home at end of life.
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