Critical Care volume 29,
Article number: 206 Published: 20 May 2025
Abstract
Endotoxin septic shock is marked by severe organ failure and
mortality rate that exceeds fifty percent, underscoring the critical need to
tailor management strategies. Monitoring -endotoxin activity can guide the
initiation and direction of adjunctive treatment for refractory septic shock
through hemoadsorption. Thus, intervening based on the pathophysiological
foundation may potentially improve outcomes. This represents a step towards
precision medicine in the management of septic shock adjunctive therapies,
addressing a knowledge gap in this pathology that remains insufficiently
defined. Despite its potential, in the setting of refractory septic shock and
multiorgan dysfunction with extreme endotoxin activity (EAA ≥ 0.9), the data about efficacy of
endotoxin hemoadsorption is scarce.
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