Renaissance of glucocorticoids in critical care in the era of
COVID-19: ten urging questions
by Martin S. Winkler, Marcin F. Osuchowski, Didier Payen,
Antoni Torres, Steffen Dickel and Tomasz Skirecki
Critical Care volume 26,
Article number: 308 (2022)
The 40-year-old experience with glucocorticosteroids (GCs)
in the context of severe infections is complex and troublesome. Recently,
however, a clear indication for GCs in severe COVID-19 has been established.
This may constitute a harbinger of a wider use of GCs in critical illnesses. A
fundamental prerequisite of such an action is a better understanding of the
heterogeneity of critical illness and GCs operationalization within the
precision medicine approach. In this perspective, we formulate ten major questions
regarding the use of GCs in critical illness. Answering them will likely
facilitate a new era of effective and personalized GCs use in modern critical
care.
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