Delirium in
COVID-19: can we make the unknowns knowns?
By: M. Elizabeth
Wilcox, Manu
Shankar-Hari & Daniel F.
McAuley
Intensive
Care Medicine (2021) Published: 30
June 2021
Delirium is an important public health problem. It is
independently associated with worse clinical outcomes, including persistent
cognitive impairment, increased mortality, and greater risk of
institutionalization. The prevalence of delirium is high in the intensive care
unit (ICU), occurring in up to 70% of the sickest patients requiring mechanical
ventilation. Early studies in hospitalized patients with coronavirus disease
2019 (COVID-19) report delirium rates of 20–30%, which increase to 60–70% in
severe illness. An international multicenter cohort study that included 69
adult ICUs across 14 countries of 2088 COVID-19 patients reported that over a
21-day period, delirium had a prevalence of 55% and lasted a median of
3 days (IQR, 2–6 days), which is more common and prolonged than that
in non-COVID cohorts…
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