by Akshay Shah, Joe N. Frost, Louise Aaron, Killian Donovan
and Hal Drakesmith
Letter to the Editor: Critical Care volume 24,
Article number: 320 (2020)
Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory coronavirus 2 (SARS-CoV-2) was declared a pandemic on March 11,
2020 [1]. Risk factors associated with
respiratory failure in patients with COVID-19 include older age, neutrophilia
and elevated inflammatory and coagulation markers [1]. Inflammation is often accompanied by
systemic hypoferremia and low iron levels may impair hypoxia sensing and
immunity [2], and increase the risk of thromboembolic
complications [3]—which are all of significant concern in
COVID-19. However, the iron status of COVID-19 patients is unclear. Therefore,
we sought to characterise iron parameters, including serum iron, in COVID-19
intensive care unit (ICU) patients and relate these to disease severity.
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