PulmCCM - November 17, 2019
Beta-blockers have generally been considered safe and
beneficial for patients with COPD, but a new randomized trial calls that
assumption into doubt. The use of oral beta blockers without a cardiac
indication appeared to double the risk of hospitalization for people
experiencing a COPD exacerbation.
Authors randomized 532 patients with moderate or
severe COPD with an exacerbation within the past year to receive either
extended release metoprolol or placebo. Patients were not already taking beta
blockers and had not had myocardial infarctions or other cardiac indications
for beta blocker use. The trial was called BLOCK-COPD and was published in the New England Journal of Medicine.
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