by Falk, Lars; Hultman,
Jan; Broman, Lars Mikael
Objectives: Septic shock carries a high mortality risk. Studies have indicated that
patients with septic shock may benefit from extracorporeal membrane
oxygenation. In most studies, patients exhibited shock due to myocardial
dysfunction rather than distributive/vasoplegic shock. One proposed theory is
that venoarterial extracorporeal membrane oxygenation alleviates a failing
myocardial function. Design:
Retrospective observational study.
Setting: Single-center, high-volume extracorporeal membrane oxygenation unit.
Patients: All patients treated for septic shock between 2012 and 2017 with an age
greater than 18 years old, fulfilling septic shock criteria according to
“Sepsis-3” at acceptance for extracorporeal membrane oxygenation, presence of
cardiocirculatory failure requiring a support equivalent to a Vasoactive
Inotropic Score greater than 50 to reach a mean arterial pressure greater than
65 mm Hg despite adequate fluid resuscitation, were included. Interventions:
None.
Measurements and Main Results: Thirty-seven patients, mean age 54.7 years
old, were included. Median Simplified Acute Physiology Score-3 score was 86 and
Sequential Organ Failure Assessment 16. Twenty-seven patients were submitted to
venoarterial and 10 patients to venovenous extracorporeal membrane oxygenation.
Hospital survival was 90% for septic shock with left ventricular failure and
64.7% in patients with distributive shock. At long-term follow-up at 46.1
months, total survival was 59.5%. Commencement of venovenous extracorporeal
membrane oxygenation and more organ failures at admission showed a less
favorable outcome in terms of hospital and long-term survival.
Conclusions: The current results add not only to the
growing evidence of the benefit of venoarterial extracorporeal membrane oxygenation
for septic cardiomyopathy but also indicate improved hospital survival in
distributive septic shock.
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