by Sébastien Tanaka, Dévy Diallo, Sandrine Delbosc, Claire
Genève, Nathalie Zappella, Jennyfer Yong-Sang, Jessica Patche, Anatole Harrois,
Sophie Hamada, Erick Denamur, Philippe Montravers, Jacques Duranteau and
Olivier Meilhac
Background
Sepsis is associated with systemic inflammation that may
impact lipoprotein function. In particular, high-density lipoproteins (HDLs)
that display pleiotropic protective roles may be dysfunctional in septic
conditions. The aim of this study was to evaluate the HDL profile and the
inflammatory context in septic shock patients admitted to our intensive care
unit (ICU).
Methods
In this study, 20 septic shock patients and 20 controls (ICU
patients without septic shock) were included. Plasma samples were collected on
days 1, 2 and 7. Total cholesterol and lipoprotein concentrations were
determined. HDL profiles were obtained using the Lipoprint® System
(non-denaturing electrophoresis). Quantification of pro-inflammatory cytokines
(interleukin 1b, 6 and 8), cell-free DNA and lipopolysaccharide-binding protein
was also performed.
Results
HDL concentration was statistically lower in septic shock
patients than in controls. At days 1 and 2, septic patients had significantly
more large-sized HDL than control patients. Patients recovered a normal lipid
profile at day 7.
Conclusions
Our results emphasize that HDL levels are dramatically
decreased in the acute phase of septic shock and that there is a shift toward
large HDL particles, which may reflect a major dysfunction of these
lipoproteins. Further mechanistic studies are required to explore this shift
observed during sepsis.
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