Two decades of mortality trends among patients with severe sepsis

Two decades of mortality trends among patients with severe sepsis. Critical care medicine, March 2014, Vol. 42(3), p.625-31.

Stevenson, E.K., et al.

http://journals.lww.com/ccmjournal/Abstract/2014/03000/Two_Decades_of_Mortality_Trends_Among_Patients.16.aspx

We searched MEDLINE for multicenter randomized trials that enrolled patients with severe sepsis from 1991 to 2009. We calculated standardized mortality ratios for each trial from observed 28-day mortality of usual care participants and predicted mortality from severity-of-illness scores. To compare mortality trends from clinical trials to administrative data, we identified adult severe sepsis hospitalizations in the Nationwide Inpatient Sample, 1993–2009, using two previously validated algorithms.