Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock

Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock: A systematic review and meta analysis. Critical care, Dec 2013, Vol. 17(6): R291

Prkno, A., et al.

http://ccforum.com/content/17/6/R291/abstract

Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcitonin-guided therapy may reduce antibiotic exposure without increasing the mortality rate. However, information on the efficacy and safety of this approach in the most vulnerable population of critically ill patients with severe sepsis and septic shock is missing.