Is this the end of the road for synthetic starches in critical illness?

Is this the end of the road for synthetic starches in critical illness? BMJ 2013, 346:f1805.

Prowle, J.R. and Pearse, R.M.

http://www.bmj.com/content/346/bmj.f1805.pdf%2Bhtml

Maintaining effective plasma volume is, perhaps, the most persistent challenge faced by clinicians who treat critically ill patients, in particular those with sepsis. In patients with sepsis, increased capillary permeability and loss of vascular tone cause loss of circulating plasma volume, which contributes to inadequate cardiac output and tissue perfusion.