A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Critical care 2012, Vol. 16: R112.
Boomer, J.S., et al.
http://ccforum.com/content/16/3/R112/abstract
Severe sepsis is characterized by an initial hyper-inflammatory response that may progress to an immune-suppressed state associated with increased susceptibility to nosocomial infection. Analysis of samples obtained from patients that died of sepsis has identified expression of specific inhibitory receptors expressed on lymphocytes that are associated with cell exhaustion. The objective of this study was to prospectively determine the pattern of expression of these receptors and immune cell function in patients with acute sepsis.
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