Lest we forget the endothelial glycocalyx in sepsis

Lest we forget the endothelial glycocalyx in sepsis. Critical Care 2012, 16, 121.

Burke-Gaffney, A.

http://ccforum.com/content/16/2/121/abstract

Sepsis is the third largest cause of death in industrialised countries, but treatment remains largely supportive and effective therapeutic interventions are urgently needed. Disruption and dysfunction of the microvascular endothelium leading directly or indirectly to multiple organ failure are now recognised to underpin the pathophysiology of sepsis.