IMPLEMENTATION OF A STANDARD PROTOCOL FOR THE SURVIVING SEPSIS 6 AND 24 HR BUNDLES IN PATIENTS WITH AN APACHE III ADMISSION DIAGNOSIS OF SEPSIS DECREA

IMPLEMENTATION OF A STANDARD PROTOCOL FOR THE SURVIVING SEPSIS 6 AND 24 HR BUNDLES IN PATIENTS WITH AN APACHE III ADMISSION DIAGNOSIS OF SEPSIS DECREASES MORTALITY IN AN OPEN ADULT ICU.

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ISSN: 0090-3493Accession: 00003246-200612002-00008Full Text (PDF) 3396 K
Author(s): Ikeda, Daniel; Hayatdavoudi, Saman; Winchell, John; Rojas, Alexandra; Rincon,
Teresa; Yee, Alan
Issue:Volume 34(12) Abstract supplement, December 2006, p A2
Publication Type:[Oral Presentations: Oral-Clinical Sepsis]
Publisher:(C) 2006 Lippincott Williams & Wilkins, Inc.
Institution(s):Sutter Health, Sacramento, CA
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Introduction:
Numerous studies have shown that individual components of the Surviving Sepsis 6
and 24 hr Bundles decrease mortality.

Hypothesis:
We hypothesized that use of a protocol implementing the Surviving Sepsis 6 and
24 hr Bundles in patients with APACHE III admission diagnosis of sepsis will
show a measurable decrease in mortality in an open adult Intensive Care Unit
(ICU).

Methods:
In this prospective study we used a protocol to manage 266 consecutive patients
admitted to a tertiary community hospital 24 bed open adult ICU from 7/1/2004 -
6/30/2006 with an APACHE III admission diagnosis of Sepsis. The historical
control cohort was 48 consecutive ICU patients admitted between 1/1/2004 -
6/30/2004 with an APACHE III admission diagnosis of Sepsis. The protocol
implemented the surviving sepsis 6 and 24 hr Bundle guidelines, using pre-printed
order sets and shared patient management by critical care physicians located in
the Sutter eICU (VISICU(R)), a remote electronic monitoring unit.

Results:
The actual ICU mortality was 40.07% in the control period, compared to 18.86%
for the study period ([chi]2 = 28.98, p

Conclusions:
Utilization of a protocol applying the Surviving Sepsis 6 and 24 hr bundle
guidelines in patients with an APACHE III admission diagnosis of Sepsis was
associated with a significant sustained decrease in mortality compared to a
historical control in a tertiary community hospital open adult ICU.