Persistent inflammation and T cell exhaustion in severe sepsis in the elderly

Persistent inflammation and T cell exhaustion in severe sepsis in the elderly. Critical Care 2014, 18: R130

Inoue, S., et al.

http://ccforum.com/content/pdf/cc13941.pdf

Sepsis is known as a complex immunological response with hyperinflammation in the acute 
phase followed by immunosuppression. Although aging is crucial in sepsis, the impact of 
aging on inflammation and immunosuppression is still unclear. The purpose of this study was 
to investigate the relationship between inflammation and immunosuppression in aged patients 
and mice after sepsis.