Persistently elevated Osteopontin serum levels predict mortality in critically ill patients

Persistently elevated Osteopontin serum levels predict mortality in critically ill patients

Critical Care 2015, 19:271  doi:10.1186/s13054-015-0988-4

Roderburg C et al

http://ccforum.com/content/19/1/271

Inflammatory, autoimmune and metabolic disorders have been associated with alterations in Osteopontin (OPN) serum levels. Furthermore, elevated serum levels of OPN were reported from a small cohort of patients with sepsis. We therefore analyzed OPN serum-concentrations in a large cohort of critically ill medical patients.
Methods: 159 patients (114 with sepsis, 45 without sepsis) were studied prospectively upon admission to the medical intensive care unit (ICU) as well as after three days of ICU treatment and compared to 50 healthy controls. Clinical data, various laboratory parameters as well as investigational inflammatory cytokine profiles were assessed. Patients were followed for approximately one year.