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Breast Surgery

Monday 31 October 2011

Gender-related outcome difference is related to course of sepsis on mixed ICUs

Gender-related outcome difference is related to course of sepsis on mixed ICUs: a prospective, observational clinical study. Critical Care 2011, 15:R151

Nachtigall, I. et al.

Impact of gender on severe infections is in highly controversial discussion with natural survival advantage of females described in animal studies but contradictory to those described human data. This study aims to describe the impact of gender on outcome in mixed intensive care units (ICUs) with a special focus on sepsis.

Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium

Impact of quetiapine on resolution of individual delirium symptoms in critically ill patients with delirium: a post-hoc analysis of a double-blind, randomized, placebo-controlled study. Critical Care 2011, 15:R215

Devlin, JW., et al.

http://ccforum.com/content/15/5/R215

The outcome of patients with delirium has been linked to the particular delirium symptoms identified with ICDSC evaluation. However, no ICU delirium prevention or treatment strategy published to date reports the impact of interventions on time to resolution of individual delirium symptoms. We hypothesized that the pattern of delirium symptom resolution would differ between patients receiving quetiapine vs. placebo. In this post-hoc analysis, we compared the delirium symptoms evaluated by the ICDSC within our previous randomized study in terms of the time to first resolution and the duration of each delirium symptom.

Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item

Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation. Critical Care 2011, 15:R229.

Nguyen, HB., et al.

Implementation of the Surviving Sepsis Campaign (SSC) guidelines has been associated with improved outcome in patients with severe sepsis. Resolution of lactate elevations or lactate clearance has also been shown to be associated with outcome. The purpose of this study was to examine the compliance and effectiveness of the SSC resuscitation bundle with the addition of lactate clearance.

Plasma from septic shock patients induces loss of muscle protein

Plasma from septic shock patients induces loss of muscle protein. Critical Care 2011, 15:R233.

van Hees, HWH, et al.

http://ccforum.com/content/15/5/R233/abstract

ICU-acquired muscle weakness commonly occurs in patients with septic shock and is associated with poor outcome. Although atrophy is known to be involved, it is unclear whether ligands in plasma from these patients are responsible for initiating degradation of muscle proteins. The aim of the present study was to investigate if plasma from septic shock patients induces skeletal muscle atrophy and to examine the time course of plasma-induced muscle atrophy during ICU stay.

Early natural killer cell counts in blood predict mortality in severe sepsis

Early natural killer cell counts in blood predict mortality in severe sepsis. Critical Care 2011, 15:R243

Andaluz-Ojeda, D., et al.

http://ccforum.com/content/15/5/R243/abstract

Host immunity should play a principal role in determining both outcome and recovery of sepsis originated by a microbial infection. Quantification of the levels of key elements of the immune response could have a prognostic value in this disease.