Effects of norepinephrine on mean systemic pressure and venous return in human septic shock

Effects of norepinephrine on mean systemic pressure and venous return in human septic shock. Critical care medicine, December 2012, Vol. 40(12), p.3146-53.

Persichini, R., et al.

http://journals.lww.com/ccmjournal/Abstract/2012/12000/Effects_of_norepinephrine_on_mean_systemic.5.aspx

Norepinephrine exerts venoconstriction that could increase both the mean systemic pressure and the resistance to venous return, but this has not yet been investigated in human septic shock. We examined the relative importance of both effects and the resulting effect on venous return when decreasing the dose of norepinephrine.