Critical Care volume 28,
Article number: 326, Published: 04 October 2024
Abstract
The optimal dosing strategy of antimicrobial agents in
critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is
unknown. We conducted comprehensive review of existing literature on effect of
ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including
antibacterials, antifungals, and antivirals that are commonly used in
critically ill patients. We aim to provide practical guidance to clinicians on
empiric dosing strategy for these patients. Finally, we discuss importance of
therapeutic drug monitoring, limitations of current literature, and future
research directions.
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