Critical Care Bulletin - December 2023

 

The International Cardiac Arrest Research Consortium Electroencephalography Database

 

by Amorim, Edilberto; Zheng, Wei-Long; Ghassemi, Mohammad M.; Aghaeeaval, Mahsa; Kandhare, Pravinkumar; Karukonda, Vishnu; Lee, Jong Woo; Herman, Susan T.; Sivaraju, Adithya; Gaspard, Nicolas; Hofmeijer, Jeannette; van Putten, Michel J. A. M.; Sameni, Reza; Reyna, Matthew A.; Clifford, Gari D.; Westover, M. Brandon 

Critical Care Medicine 51(12):p 1802-1811, December 2023.

 

OBJECTIVES: 

To develop the International Cardiac Arrest Research (I-CARE), a harmonized multicenter clinical and electroencephalography database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest.

DESIGN: 

Multicenter cohort, partly prospective and partly retrospective.

SETTING: 

Seven academic or teaching hospitals from the United States and Europe.

PATIENTS: 

Individuals 16 years old or older who were comatose after return of spontaneous circulation following a cardiac arrest who had continuous electroencephalography monitoring were included.

INTERVENTIONS: 

Not applicable.

MEASUREMENTS AND MAIN RESULTS: 

Clinical and electroencephalography data were harmonized and stored in a common Waveform Database-compatible format. Automated spike frequency, background continuity, and artifact detection on electroencephalography were calculated with 10-second resolution and summarized hourly. Neurologic outcome was determined at 3–6 months using the best Cerebral Performance Category (CPC) scale. This database includes clinical data and 56,676 hours (3.9 terabytes) of continuous electroencephalography data for 1,020 patients. Most patients died (n = 603, 59%), 48 (5%) had severe neurologic disability (CPC 3 or 4), and 369 (36%) had good functional recovery (CPC 1–2). There is significant variability in mean electroencephalography recording duration depending on the neurologic outcome (range, 53–102 hr for CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in frequency for at least 1 hour was seen in 258 patients (25%) (19% for CPC 1–2 and 29% for CPC 3–5). Burst suppression was observed for at least 1 hour in 207 (56%) and 635 (97%) patients with CPC 1–2 and CPC 3–5, respectively.

CONCLUSIONS: 

The I-CARE consortium electroencephalography database provides a comprehensive real-world clinical and electroencephalography dataset for neurophysiology research of comatose patients after cardiac arrest. This dataset covers the spectrum of abnormal electroencephalography patterns after cardiac arrest, including epileptiform patterns and those in the ictal-interictal continuum.