Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

Daniel E. Leisman, Clifford S. Deutschman & Matthieu Legrand 

Intensive Care Medicine (2020)Cite this article Published: 28 April 2020

 Current management guidelines for COVID-19 reflect the assumption that critically ill patients infected with SARS-CoV-2 develop acute respiratory distress syndrome (ARDS). However, emerging data and clinical reports increasingly suggest an alternative view that severe COVID-19 reflects a confluence of vascular dysfunction, thrombosis, and dysregulated inflammation…