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Breast Surgery

Wednesday, 3 July 2019

Heparin-binding protein in sepsis: player! predictor! positioning?

by Patrick M. Honore, David De Bels, Leonel Barreto Gutierrez, Sebastien Redant and Herbert D. Spapen 

In a post hoc study of the multicenter FINNAKI trial, Tverring et al. recently reported that measuring heparin-binding protein (HBP) on admission in the intensive care unit (ICU) improved prediction of sepsis-induced acute kidney injury (AKI). In addition, high plasma HBP levels were associated with a significantly higher fluid balance within 24 h, more organ failure within the first week, and increased 28-day mortality [1]. These observations support HBP as a novel prominent pawn on the already well-stuffed AKI biomarker chessboard…

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