Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients

Midazolam and propofol used alone or sequentially for long-term sedated, critically ill patients: a prospective, randomized study. Critical Care 2014, 18: R122 

Zhou, Y., et al.

http://ccforum.com/content/pdf/cc13922.pdf

Midazolam and propofol used alone for long-term sedation are associated with adverse effects. Sequential use may reduce the adverse effects, and lead to faster recovery, earlier extubation and lower costs. This study evaluates the effects, safety, and cost of midazolam, propofol, and their sequential use for long-term sedation in critically ill mechanically ventilated patients.