Early alterations of B cells in patients with septic shock: another piece in the complex puzzle of the immune response in sepsis

Early alterations of B cells in patients with septic shock: another piece in the complex puzzle of the immune response to sepsis. Critical care, 2013, 17: 162

Girardis, M. and Cossarizza, A.

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Impairment of the inflammatory-immune response is currently accepted as a hallmark of severe sepsis even in the early stages of the disease. In this context, the alterations of the circulating B-lymphocytes have never been described in detail. The study by Monserrat and colleagues in the previous issue of Critical Care indicated that, in patients with septic shock, the B-cell compartment is early and deeply altered with different patterns in subset distribution and activation between survivors and non-survivors.