Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Critical care medicine, May 2012, Vol. 40(5), p.1404-09.
Heenen, S., et al.
http://journals.lww.com/ccmjournal/Abstract/2012/05000/Antibiotic_strategies_in_severe_nosocomial_sepsis_.2.aspx
We reviewed all episodes of severe sepsis treated over a 1-yr period in the department of intensive care. Antimicrobial therapy was considered as appropriate when the antimicrobial had in vitro activity against the causative microorganisms.
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