Plasma from septic shock patients induces loss of muscle protein

Plasma from septic shock patients induces loss of muscle protein. Critical Care 2011, 15:R233.

van Hees, HWH, et al.

http://ccforum.com/content/15/5/R233/abstract

ICU-acquired muscle weakness commonly occurs in patients with septic shock and is associated with poor outcome. Although atrophy is known to be involved, it is unclear whether ligands in plasma from these patients are responsible for initiating degradation of muscle proteins. The aim of the present study was to investigate if plasma from septic shock patients induces skeletal muscle atrophy and to examine the time course of plasma-induced muscle atrophy during ICU stay.