Are we sedating more than just the brain? Critical Care 2011 15:163
Brummel, NE and Girard TD.
Heavy sedation in the ICU is associated with coma, delirium, and prolonged stays, but links between sedatives and non-brain organ failure have rarely been described. In a post-hoc analysis, Strom et al. explored associations between sedation and acute kidney injury among ICU patients randomized to one of two sedation strategies. The "no sedation" protocol was associated with less kidney injury, but methodologic limitations preclude firm conclusions regarding mechanisms underlying this association. This hypothesis-generating study warns that sedation may harm organs other than the brain during critical illness, a possibility that warrants careful study in the future.
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