Targeting high circulating dipeptidyl peptidase 3 in circulatory failure

Critical Care volume 29, Article number: 340, Published: 31 July 2025

Abstract

Circulating dipeptidyl peptidase 3 is a new biomarker linked to circulatory failure prognosis and pathophysiology and is a potential actionable therapeutic target. In this short review intended for the clinician, a question-and-answer format provides key insights on the nature of this biomarker and the therapeutical potential of its targeted inhibition in critically ill patients.