Goal-directed resuscitation for patients with early septic shock

Goal-directed resuscitation for patients with early septic shock. NEJM, October 2014 [online]

The ARISE Investigators and the ANZICS Clinical Trials Group

http://www.nejm.org/doi/full/10.1056/NEJMoa1404380?af=R&rss=currentIssue

Early goal-directed therapy  has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain.